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KMID : 0377519790040010065
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Chung-Ang Journal of Medicine
1979 Volume.4 No. 1 p.65 ~ p.71
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Effects of the Levamisole on the Ehrlich Ascites Tumor
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Kang Sang-Kyoon
Kim Moo-Chul
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Abstract
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Since B.C.G. was introduced into immune therapy of cancer several biologic as well as chemical immune therapy was established. The mechanisms of anticancerous effect by these agents were still unproved, however, many authors believe that immune system stimulation plays major role. Levamisole is one of antiparasitic drug which showed anticancerous effect in experimental animal by way of immune stimulation. Ehrlich ascites tumor was implanted into the mouse peritoneal cavity, then Levamisole effect was observed in this experiment. Levamisole was administered intraperitoneally and subcutaneouslly to the experimental animals. Single, three, four and seven times of doses were given to each animal group respectively. Survival day to experimental animal is compared with control group, and survival rate was observed. Obtained results were follows; 1. Mean survival days of control group was 10.8 days, while Levamisole administered prolongation. Increment of survival rate was range of 31.5-42.6% in the experimental groups. 2. The most prolonged survival days were seen in intraperitoneal single doses of Levamisole administered group. 3. The difference of dose or method of Levamisole administration showed no significant difference of survival day and rate of the experimental animal groups. The above results suggest anticancerous effect of Levamisole upon the Ehrlich ascites tumor cells by chemical stimulation.
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